Publications

Publicationsp13
KAHR-101

1. Fn14-TRAIL, a chimeric intercellular signal converter, attenuates experimental autoimmune encephalomyelitis. Marjaneh Razmara, Brendan Hilliard, Azadeh K. Ziarani, Ramachandran Murali, Sri Yellayi, Mustafa Ghazanfar, Youhai H. Chen, and Mark L. Tykocinski.; Am. J. Pathol. 2009 Feb; 174 (2). Download PDF.

2. Amelioration of autoimmune neuroinflammation by the fusion molecule Fn14•TRAIL. Hodaya Prinz-Hadad, Tehila Mizrachi, Michal Irony-Tur-Sinai, Tatyana B Prigozhina, Talma Brenner and Michal Dranitzki-Elhalel. Journal of Neuroinflammation 2013, 10:36. Download PDF

3. Fn14•Trail Effectively Inhibits Hepatocellular Carcinoma Growth. Alexandra Aronin, Shira Amsili, Tatyana B. Prigozhina, Kobi Tzdaka, Jacob Rachmilewitz, Noam Shani, Mark L. Tykocinski and Michal Dranitzki Elhalel. PLOS ONE, 2013, Volume 8, Issue 10. Download PDF

KAHR-102

1. CTLA4-Fas ligand functions as a trans signal converter protein in bridging antigen-presenting cells and T cells. Huang JH, Tykocinski ML.; Int. Immunol. 2001 Apr;13(4):529-39. Download PDF

2. CTLA-4-FasL induces alloantigen-specific hyporesponsiveness. Elhalel MD, Huang JH, Schmidt W, Rachmilewitz J, Tykocinski ML.; J. Immunol. 2003 Jun 15;170(12):5842-50. Download PDF

3. Simultaneous stimulation of Fas-mediated apoptosis and blockade of costimulation prevent autoimmune diabetes in mice induced by multiple low-dose streptozotocin. Jin Y, Qu A, Wang GM, Hao J, Gao X, Xie S.; Gene Ther. 2004 Jun;11(12):982-91. Download PDF

4. CTLA4-Fas ligand gene transfer mediated by adenovirus induce long-time survival of murine cardiac allografts. Feng YG, Jin YZ, Zhang QY, Hao J, Wang GM, Xie SS.; Transplant Proc. 2005 Jun;37(5):2379-81. Download PDF

5. CTLA-4-FasL inhibits allogeneic responses in vivo. Dranitzki-Elhalel M, Huang JH, Rachmilewitz J, Pappo O, Parnas M, Schmidt W, Tykocinski ML.; Cell Immunol. 2006 Feb;239(2):129-35. Epub 2006 Jul 7. Download PDF

6. CTLA-4•FasL induces early apoptosis of activated T cells by interfering with anti-apoptotic signals. Orbach A, Rachmilewitz J, Parnas M, Huang J-H, Tykocinski ML and Dranitzki-Elhalel M.; J. Immunol, 2007 179: 7287-7294 Download PDF

7. Prolongation of corneal allograft survival by CTLA4-FasL in a murine model. Weiyun Shi & Min Chen & Lixin Xie. Graefe’s Arch Clin Exp Ophthalmol, 2007, 245:1691–1697 Download PDF

8. CD40-FasL and CTLA-4-FasL Fusion Proteins Induce Apoptosis in Malignant Cell Lines by Dual Signaling. Ariel Orbach, Jacob Rachmilewitz, Noam Shani, Yonatan Isenberg, Miriam Parnas, Jui-Han Huang, Mark L. Tykocinski and Michal Dranitzki-Elhalel; Amer. J. Path. Vol. 177, No. 6, December 2010 Download PDF

9. CTLA4-FasL fusion product suppress proliferation of fibroblast-like synoviocytes and progression of adjuvant-induced arthritis in rats. Wei Zhang, Bo Wang, Fang Wang, Jin Zhang, Jiyun Yu, Molecular Immunology 50:150– 159, 2012 Download PDF

10. Design, expression and characterization of a novel coexpression system of two antiarthritic molecules. Wei Zhang, Fang Wang, Jinqi Yan, Xiaojun Zhang, Yu Wang, Yunbo Jiang, Lin Wang, Yuanji Xu, Jiyun Yu. Appl Microbiol Biotechnol (2013) 97:6301–6314. Download PDF

11.Highly efficient, In-vivo Fas-mediated Apoptosis of B-cell Lymphoma by Hexameric CTLA4-FasL. Alexandra Aronin, Shira Amsili, Tatyana B Prigozhina, Kobi Tzdaka, Roy Shen, Leonid Grinmann, Fanny Szafer, Per Edebrink, Mari-Anne Rauvola, Noam Shani, Michal Dranitzki Elhalel. Journal of Hematology & Oncology 2014, 7:64. Download PDF

Other DSPs:

1. CD40-FasL inhibits human T cells: evidence for an auto-inhibitory loop-back mechanism. M. Dranitzki-Elhalel, J. H. Huang, M. Sasson, J. Rachmilewitz, M. Parnas and M. L. Tykocinski.; International Immunology, 2007, Vol. 19, No. 4, 355–363
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2. CD40-FasL and CTLA-4-FasL Fusion Proteins Induce Apoptosis in Malignant Cell Lines by Dual Signaling. Ariel Orbach, Jacob Rachmilewitz, Noam Shani, Yonatan Isenberg, Miriam Parnas, Jui-Han Huang, Mark L. Tykocinski and Michal Dranitzki-Elhalel; Amer. J. Path. Vol. 177, No. 6, December 2010 Download PDF

Reviews and Book Chapters

1. A Tapestry of Immunotherapeutic Fusion Proteins: From Signal Conversion to Auto-stimulation. Mark L. Tykocinski, Jui-Han Huang, Matthew C. Weber and Michal Dranitzki-Elhalel. Chapter 38, National Institute of Allergy and Infectious Diseases, NIH: Volume1. Frontiers in Research. 2008 Download PDF